Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses

NK Khankari; XO Shu; W Wen; P Kraft; S Lindström; U Peters; J Schildkraut; FR Schumacher; P Bofetta; A Risch; H Bickeböller; CI Amos; DF Easton; RA Eeles; SB Gruber; CA Haiman; DJ Hunter; SJ Chanock; BL Pierce; W Zheng; K Blalock; PT Campbell; G Casey; DV Conti; CK Edlund; J Figueiredo; W James Gauderman; J Gong; RC Green; JF Harju; TA Harrison; EJ Jacobs; MA Jenkins; S Jiao; L Li; Y Lin; FJ Manion; V Moreno; B Mukherjee; L Raskin; D Seminara; G Severi; SL Stenzel; DC Thomas; JL Hopper; MC Southey; E Makalic; DF Schmidt; O Fletcher; J Peto; L Gibson; I dos Santos Silva; H Ahsan; A Whittemore; Q Waisfisz; H Meijers-Heijboer; M Adank; RB van der Luijt; AG Uitterlinden; A Hofman; A Meindl; RK Schmutzler; B Müller-Myhsok; P Lichtner; H Nevanlinna; TA Muranen; K Aittomäki; C Blomqvist; J Chang-Claude; R Hein; N Dahmen; L Beckman; L Crisponi; P Hall; K Czene; A Irwanto; J Liu; DF Easton; C Turnbull; N Rahman; Z Kote-Jarai; K Muir; G Giles; D Neal; JL Donovan; FC Hamdy; F Wiklund; H Gronberg; R Travis; E Riboli; S Gapstur; S Berndt; Y Han; L Su; Y Wei; RJ Hung; Y Brhane; J McLaughlin; P Brennan; JD McKay

Journal article

Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses

NK Khankari, XO Shu, W Wen, P Kraft, S Lindström, U Peters, J Schildkraut, FR Schumacher, P Bofetta, A Risch, H Bickeböller, CI Amos, DF Easton, RA Eeles, SB Gruber, CA Haiman, DJ Hunter, SJ Chanock, BL Pierce, W Zheng Show all

Plos Medicine | Published : 2016

DOI: 10.1371/journal.pmed.1002118

Abstract

Background: Observational studies examining associations between adult height and risk of colorectal, prostate, and lung cancers have generated mixed results. We conducted meta-analyses using data from prospective cohort studies and further carried out Mendelian randomization analyses, using height-associated genetic variants identified in a genome-wide association study (GWAS), to evaluate the association of adult height with these cancers. Methods and Findings: A systematic review of prospective studies was conducted using the PubMed, Embase, and Web of Science databases. Using meta-analyses, results obtained from 62 studies were summarized for the association of a 10-cm increase in height..

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University of Melbourne Researchers

Mark Jenkins Author

Melissa Southey Author

Enes Makalic Author

Daniel Schmidt Author Melbourne School of Population and Global Health

Related Projects (1)

COMPREHENISVE MODEL FOR COLORECTAL CANCER RISK

I am a genetic epidemiologist focused on bowel cancer risk. I will develop a comprehensive model to estimate individual cancer risk by study..

Grants

Awarded by National Cancer Institute

Funding Acknowledgements

The work for this project at Vanderbilt University was supported primarily by US NIH (http://www.nih.gov) grant R37CA070867 and by funds from the Ingram Professorship and Anne Potter Wilson endowments. NKK was supported by NIH grant R25CA160056-03. The Post-Cancer GWAS (GAMEON) initiative was supported by NIH grants U19CA148065 (DRIVE, PI: DJH), U19CA148107 (CORECT, PI: SBG), U19CA148127 (TRICL, PI: CIA), and U19CA148537 (ELLIPSE, PI: CAH). RAE is supported by Cancer Research UK (http://www.cancerresearchuk.org/), Prostate Cancer UK (http://prostatecanceruk.org/), The Institute of Cancer Research (http://www.icr.ac.uk/), and Royal Marsden Biomedical Research Centre, which receives support from the National Institute of Health Research (http://www.nihr.ac.uk) (C5047/A17528). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.